At the present time, space travel is characterized by separately developed technologies of the space-traveling nations. Depending on fixed financial budgets and expensive technology companies, the developed spaceships are strongly designed just for a specific mission profile in order to reduce costs and risks as far as possible. Because of their less sustainable supply concept, these spacecraft allow only a limited mission duration and require regular supply deliveries in addition. Instead, the space mission durations will permanently increase with the planned exploration of Moon, Mars, asteroids, or other objects that are even more distant. These missions will require high sustainable supply concepts in order to enable autonomous and long-term life support of human mission participants. The now existing solutions do not yet meet these requirements, so the current approach of spacecraft design had to undergo a conceptual review. The research made in the context of this work led to the design of a new generation of spacecraft that supports with its optimized hull construction such extended long-term missions in terms of durability, variability, and life support. All its embedded biological and chemical processes have, on the one hand side, the primary aim to enable humans a long stay in space and, on the other hand side, to be independent of an external mission supply. The performed research activities also included the necessary mechanical and energetical functions for which an extreme lifetime extension of up to 60 years was aimed.