the results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that little progress has been made in the treatment of cancer. few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value of adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations of surgery and radiotherapy. this book authoritatively reviews the rationale for, results of, special problems, and future directions of adjuvant therapy of breast cancer. it also includes an appendix from the early breast cancer trialists collaborative group (oxford, u.k.) which lists all of the adjuvant trials which have been closed, as well as the active studies now ongoing.