This book constitutes the refereed proceedings of the 6th International Conference on Information and Knowledge Systems, ICIKS 2023, held in Portsmouth, UK, during June 22-23, 2023.The 18 full papers and 6 short papers included in this book were carefully reviewed and selected from 58 submissions. They were organized in topical sections as follows: Decision Making, Recommender Systems, and Information Support Systems; Information Systems and Machine Learning; Knowledge Management, Context and Ontology; Cybersecurity and Intelligent Systems; and Natural Language Processing for Decision Systems.