this volume highlights recent advances in the basic mechanisms of the immunopathogenesis of multiple sclerosis. written by scientists actively involved in leading research, it mainly focuses on aspects of autoreactive t cell activation. progress in the field of blood-brain barrier damage pathophysiology, antigen presentation in the central nervous system and magnetic resonance imaging are also reported. providing a rapid access to up-to-date, leading research on basic pathogenetic mechanisms of multiple sclerosis, this book is directed not only to neuroimmunologists, but also to a general neurological readership.