It is clear that our approach to identifying the root cause of Alzheimer's disease and curing it has not been successful so far despite decades of research, billions of dollars spent worldwide, 244 experimental drugs developed, and many clinical trials that have failed. What is happening? Have we got the cause of Alzheimer's all wrong? I believe so! Instead of remaining focused on the primary endpoint of a cure, the emphasis had shifted to surrogate endpoints that had not been clinically demonstrated to correlate well with the disease. In this book, I identify the root cause of the disease and attempt to reorient our approach along a path that I am convinced will be more successful in leading us to a cure. I will provide the outlines of this new approach and even suggest the methodology to be followed. At the same time, I am also hoping to be able to co-opt the support I need from the general public, particularly those already afflicted by the disease or fearing they might succumb to it, as well as their families, friends, and caregivers. For them, I will also try to demystify the disease and describe ways they can do something about it in addition to seeking medical treatment.