despite its wide recognition as a serious public health problem, anaphylaxis and hypersensitivity reactions remain under-recognized and under-diagnosed. this book fills the gaps in the recognition of clinical presentation and triggers, the understanding of the natural history of these reactions, and the selection of treatment strategies including cellular and molecular targets. the book provides a detailed examination of etiology, pathogenesis, and pathophysiology and their correlation to clinical practice. the mediators and mechanisms of anaphylaxis are described and specific causal factors are covered with emphasis on current and emerging therapies. this book is a valuable resource for clinicians as well as translational and basic researchers.