Historical Background of Diabetic Kidney DiseaseReview of Clinical Practice Guidelines I. Natural Course, Pathogenesis, Morphology and GeneticsDiabetic Kidney Disease: Scope of the ProblemNatural CoursePathogenesis: Hemodynamic alterationsPathogenesis: Structural Changes in the Kidneys in Type 1 and Type 2 DiabetesDiabetes in Children and Adolescents II. Clinical Presentation and Associated ConditionsScreening, Early Diagnosis, Genetic markers and Predictors of ProgressionAtypical PresentationsAlbuminuria and ProteinuriaHypertension and DiabetesObesity and Metabolic SyndromeAnemia and DiabetesCarvdiovascular Disease and DiabetesDyslipidemia and DiabetesBone Disease and DiabetesDiabetic RetinopathyPregnancy and DiabetesKidney Transplantation and Kidney Pancreas TransplantationDiabetic Kidney Disease and Covid-19 III. Treatment and PrognosisGlycemic ControlComputerized Clinical Decision SupportAntihypertensive therapiesMetforminSodium-glucose Cotransporter-2 (SGLT2) InhibitorsGlucagon-like Peptide-1 Receptor Agonists (GLP1-RA)Dipeptidyl Peptidase-4 (DPP4) InhibitorsNovel Treatments and the Future of DKD: What is on the Horizon?Putting it All Together: Practical Approach to the Patient with Diabetic Kidney Disease