As globalization continues to increase interdependence, risk transcends national borders, causing major challenges in risk governance. This is particularly well illustrated in the health sector. Epidemics and pandemics know no borders and are often characterized by a high level of uncertainty regarding the causality of risk and its potential, social and economic consequences. How these risks are addressed at the international level and what role international organizations take in facing them lie at the heart of the book. The analysis of the severe acute respiratory syndrome (SARS), the avian influenza (H5N1) and the (A)H1N1 influenza pandemic in 2009 shows the emergence of global risk governance processes and the key role that multilateral institutions, in particular the World Health Organization (WHO), play within them.