This book examines John Keats's immensely important collection of poems, Lamia, Isabella, The Eve of St Agnes, And Other Poems (1820), and is published in the volume's bicentenary. It analyses the collection as an authorially organised and multi-dimensionally unified volume rather than as a collection of occasional poems. R. S. White argues that a guiding theme behind the 1820 volume is the persistent emphasis on different types of melancholy, an ancient, all-consuming medical condition and literary preoccupation in Renaissance and Romantic poetry. Melancholy was a lifelong interest of Keats's, touching on his medical training, his temperament and his delighted reading in 1819 of Burton's The Anatomy of Melancholy.