Since 2012, Life of Mine has sought to promote holistic thinking across all aspects of a mine's life cycle. This edition further strengthens this vision, with the most extensive program to date including over 40 technical presentations. This reflects the recent growing activity and interest in this space, driven by regulatory landscape changes and associated responses from industry and researchers. The conference proceedings showcases examples and case studies of applying interdisciplinary approaches that enhance outcomes, increase efficiencies and improve effectiveness to address current and future challenges facing the industry. These challenges include increasing cost and production pressures, ever-demanding technical factors, and increasing societal and community expectations.