The shortage of human dietary protein can be provided by fish protein, particularly in developing countries, however, this goal may be difficult due to the high cost of good quality fish meals which costs about 40-60% of total input costs in intensive aquaculture enterprises. Nowadays, probiotics are becoming an integral part of the aquaculture practices to obtain high production. Probiotics are live microorganisms which are beneficial to the host organism. The involvement of probiotics in nutrition, disease resistance and other beneficial activities in fish has proven beyond doubt. Among the numerous health benefits attributed to probiotics, modulation of immune system is one of the most commonly purported benefits of the probiotics and their potency to stimulate the systemic and local immunity. The use of immunostimulants to enhance activities in the immune system has been given considerable attention in aquaculture in order to increase disease resistance in farmed fish. The present work reports the effect of probiotic supplement diet on growth performance and resistance against Aeromonas hydrophila in Labeo icar fingerlings.