The story is set in Padua, Italy, in a distant and unspecified past. From his quarters, Giovanni Guasconti, a young student of letters, at the University of Padua, looks at Beatrice, the beautiful daughter of Dr. Giacomo Rappaccini, a scientist who works in isolation. Beatrice is confined to the lush and locked gardens, which are filled with poisonous plants grown by her father. Giovanni notices Beatrice's strangely intimate relationship with the plants as well as the withering of fresh flowers and the death of an insect when exposed to her skin or breath.