This issue of Surgical Oncology Clinics of North America, Guest Edited by John M. Kane III, MD, is devoted to Sarcomas. Articles in this issue include: Prognostic Factors and Staging for Soft Tissue Sarcomas; Margin Status and Local Recurrence: Correlation or Causation?; Systemic Chemotherapy in the Adjuvant and Clinical Metastatic Setting; Pulmonary Metastasectomy; Regional Therapy for Advanced Extremity Sarcomas; Current Approaches to Retroperitoneal Sarcomas; Updates on the Management of Gastrointestinal Stromal Tumors (GIST); Soft Tissue Sarcoma: Immunologic Implications; Atypical Lipomatous Tumor/Well Differentiated Liposarcoma: What is it?; Modern Surgical Therapy: Limb Salvage and the Role of Amputation; Adjuvant Radiation Therapy: and Preoperative, Postoperative, or Not at All.