Search for Liberation is mainly comprised of interviews and conversations between His Divine Grace A.C. Bhaktivedanta Swami Prabhupāda and John Lennon and his wife, Yoko Ono. The featured conversation takes place at John's Tittenhurst estate in mid-September of 1969, when Śrīla Prabhupāda and some of his students were staying there as guests. Many topics were discussed, including how to attain peace and liberation from material existence, the eternality of the soul, re-incarnation, the qualifications of a bonafide spiritual master, the importance of the Bhagavad-Gītā, and the supremacy of the Hare Kṛṣṇa mahāmantra. Śrīla Prabhpāda handles all the inquiries with personal concern, while addressing the issues of the times with great relevancy.