Spirituality is a highly developed thought process of the human brain, which is there in the coding of our DNA. It happens because of millions and millions of years of natural evolutionary and developmental mechanism and put the human beings at the apex of the animal kingdom.Spiritual thought processes and Spiritual Health are considered essential dimensions of human health. How can we define spirituality and Spiritual Health in the context of scientific, religious and cultural grounds? How can the concept of Spiritual Health improve our spirituality in every area of our life including religion, science, and culture? How spirituality and religiosity have the ambiguities in their definitions and expressions and why it requires clarity and needs to be understood in the light of scientific reasoning? How spirituality and Spiritual Health can act as an excellent preventive and promotive tool in physical, mental and social health? A paradigm shift in our understanding the whole concept of spirituality and Spiritual Health.