Mighty-Girl and friends are back with a new adventure. Vincent Fasendone; a long-time nemesis of Mighty-Girl's has been locked up in a federal prison for nearly a decade now,but he then hatches a plot to escape prison and is successful. Mr. Fasendone then embarks on a vicious plan to put Mighty-Girl out of business for good.He hatches a plot to have Mighty-Girl drugged which makes her uncharacteristically aggressive but when Mighty-Girl's alter-ego,Carol Anne also exhibits these dangerously aggressive traits Mr. Fasendone's plan's going better than he could've expected and it's up to Electra-Girl and Aqua-Girl; Mighty-Girl's trusted sidekicks to uncover the plot before it's too late.