Volume 70 of Reviews in Mineralogy and Geochemistry represents an extensive review of the material presented by the invited speakers at a short course on Thermodynamics and Kinetics of Water-Rock Interaction held prior to the 19th annual V. M. Goldschmidt Conference in Davos, Switzerland (June 19-21, 2009). Contents: Thermodynamic Databases for Water-Rock InteractionThermodynamics of Solid Solution-Aqueous Solution SystemsMineral Replacement ReactionsThermodynamic Concepts in Modeling Sorption at the Mineral-Water InterfaceSurface Complexation Modeling: Mineral Fluid Equilbria at the Molecular ScaleThe Link Between Mineral Dissolution/Precipitation Kinetics and Solution ChemistryOrganics in Water-Rock InteractionsMineral Precipitation KineticsTowards an Integrated Model of Weathering, Climate, and Biospheric ProcessesApproaches to Modeling Weathered RegolithFluid-Rock Interaction: A Reactive Transport ApproachGeochemical Modeling of Reaction Paths and Geochemical Reaction Networks