Libro A Novel Approach of Formulation of Doxorubicin Drug Conjugate De Kothari, Richa

portada A Novel Approach of Formulation of Doxorubicin Drug Conjugate

Formato

Libro Físico

Autor

Richa Kothari

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.3 cm

Peso

0.09 kg.

ISBN13

9786206142645

Categorías

Farmacología

A Novel Approach of Formulation of Doxorubicin Drug Conjugate

Richa Kothari (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "A Novel Approach of Formulation of Doxorubicin Drug Conjugate"

In the present study a series of Cu (II) complexes of Schiff base molecular adducts of doxorubicin have been synthesized and characterized by analytical, molar conductance, IR electronic magnetic susceptibility and powder XRD measurements and screened for various biological activities (antioxidants, and cytotoxicity). In all the Cu (II) complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non- electrolytic in nature. Based on the electronic and magnetic data, an distorted octahedral geometry is ascribed for all the copper (II) complexes. All Cu (II) complexes showed considerable anticancer activity against MCF-7 cell lines and more pronounced antioxidant activity lines and more pronounced antioxidant activity in the presence of DPPH. The newly synthesized title compounds were evaluated for their MCF-7 cell growth inhibition, the results revealed that all the tested compounds possess inhibitory effects on the growth of MCF-7 cancer cells. Compound 3 showed the highest inhibition activity against MCF-7 cell line (IC50 7.21 0.1 μg/ml) among all tested Compounds.