Name: aminoglycoside antibiotics (en Inglés)
Price: 160070.00 CLP
Availability: InStock
Author: Umezawa, Hamao ; Hooper, Irving R. ; Ito, Y.
ISBN: 9783642685811

portada aminoglycoside antibiotics (en Inglés)

Formato

Libro Físico

Contribuciones de

Ilustrado por

Editorial

Autor

Umezawa, Hamao ; Hooper, Irving R. ; Ito, Y.

Año

2011

Idioma

Inglés

N° páginas

372

Encuadernación

Tapa Blanda

Dimensiones

24.4 x 17.0 x 2.1 cm

Peso

0.62 kg.

ISBN

3642685811

ISBN13

9783642685811

Categorías

Farmacología
Farmacia y prescripción

aminoglycoside antibiotics (en Inglés)

Y. Ito (Contribuciones de) · Hamao Umezawa (Ilustrado por) · Irving R. Hooper (Contribuciones de) · Springer · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "aminoglycoside antibiotics (en Inglés)"

The first useful antibiotic found by screening was streptomycin. The late Prof. WAKSMAN started screening for antibacterial antibiotics in 1940 and, after finding actinomycin in 1941, he and his collaborators discovered streptomycin in 1944. This antibiotic made a great contribution in saving human lives from tuberculosis and acute serious infections. About 1957, after wide usage of such antibiotics as penicillin, streptomycin, chloramphenicol, tetracycline, and erythromycin, staphy- lococci and Gram negative organisms resistant to all or most antibiotic drugs ap- peared in hospital patients. The origin and treatment of such resistant strains be- came a major topic of investigation. At that time, kanamycin was discovered and used in the treatment of resistant infections. It may be said that the appearance of resistant strains stimulated a resurgence of research on new antibacterial antibiot- ics and their derivatives. In 1965, kanamycin-resistant strains were found in hospital patients and, undertaking the study of the mechanisms of resistance, I found that resistant strains produce intracellular enzymes that can transfer either the terminal phos- phate of ATP or the acetate of acetyl-CoA to the 3' -hydroxyl or the 6' -amino group of 2-deoxystreptamine containing antibiotics. These results, reported in 1967, made it possible to design new synthetic derivatives that would inhibit the growth of kanamycin resistant strains of microorganisms. Thus, a new research area was opened: the development of aminoglycosides useful in the treatment of drug-resis- tant infections.