Name: Capsaicin and Pain: Morphological and Phenotypic Changes After Neurotmesis and Perineural Capsaicin Treatment (en Inglés)
Price: 43340.00 CLP
Availability: InStock
Author: Csaba Szigeti; Péter Sántha; Gábor Jancsó
ISBN: 9783659402449

portada Capsaicin and Pain: Morphological and Phenotypic Changes After Neurotmesis and Perineural Capsaicin Treatment (en Inglés)

Formato

Libro Físico

Editorial

Lap Lambert Academic Publishing

Autor

Csaba Szigeti; Péter Sántha; Gábor Jancsó

Año

2013

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

ISBN13

9783659402449

Categorías

Cuestiones generales de la medicina

Capsaicin and Pain: Morphological and Phenotypic Changes After Neurotmesis and Perineural Capsaicin Treatment (en Inglés)

Csaba Szigeti; Péter Sántha; Gábor Jancsó (Autor) · Lap Lambert Academic Publishing · Tapa Blanda

Libro Físico

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Reseña del libro "Capsaicin and Pain: Morphological and Phenotypic Changes After Neurotmesis and Perineural Capsaicin Treatment (en Inglés)"

Different types of mechanical, chemical and metabolic injuries may damage peripheral nerves and produce impairments in sensory, motor and autonomic functions. Transection of peripheral nerves results in neurotmesis, the most severe form of nerve injury characterized by a complete division of the nerve, which may be associated with neuropathic pain and related painful dysaesthesias. It was suggested that both the axotomy- and the perineural capsaicin treatment-induced reductions in the sensitivity of primary afferent neurons to capsaicin might be related to a downregulation of the capsaicin/TRPV1 receptor. Changes in TRPV1 protein/mRNA level were investigated with in situ hybridization, quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot analysis. Our results suggest the involvement of distinct cellular mechanisms in the regulation of the TRPV1 mRNA expression of damaged neurons, specifically triggered by the nature of the injury. The antinociceptive and anti-inflammatory effects of perineurally applied capsaicin involve distinct changes in neuronal TRPV1 mRNA expression and long-lasting alterations in (post)translational regulation.