Name: Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine (en Inglés)
Price: 93510.00 CLP
Availability: InStock
Author: Pandit, Vinay ; Sharma, Priyanka ; Ashawat, M. S.
ISBN: 9786202524209

portada Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine (en Inglés)

Formato

Libro Físico

Autor

Priyanka Sharma

Vinay Pandit

M. S. Ashawat

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

116

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.7 cm

Peso

0.18 kg.

ISBN13

9786202524209

Categorías

Farmacología

Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine (en Inglés)

Priyanka Sharma (Autor) · Vinay Pandit (Autor) · M. S. Ashawat (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine (en Inglés)"

Emesis is the involuntary and forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Receptors on the floor of the ventricle of the brain represent a chemo-receptor trigger zone, known as the area postrema, stimulation of which can lead to vomiting. Chlorpromazine HCl is formulated as a sublingual film. The films formed by HPMC K-15 at a concentration of 120 mg showed the desirable character for a sublingual film. The optimized films formed were subjected to evaluation parameters viz. Tensile Strength, Disintegration, In-vitro dissolution, Ex-vivo Permeation studies and In-vivo studies and the results complied with the available statistical data. In-vitro dissolution studies were analyzed and Higuchi model was found to be the best fit model for In-vitro dissolution studies with a regression value of 0.9248. Ex-vivo permeation studies showed fivefold enhanced permeation of drug from films as compared to pure drug. In conclusion, a sublingual film of Chlorpromazine HCl may result in better patient compliance, quick onset of action and enhanced bio-availability.