Name: Lipid Peroxidation Research (en Inglés)
Price: 160740.00 CLP
Availability: InStock
Author: Mansour, Mahmoud Ahmed
ISBN: 9781839685477

portada Lipid Peroxidation Research (en Inglés)

Formato

Libro Físico

Editorial

Intechopen

Autor

Mansour, Mahmoud Ahmed

Idioma

Inglés

N° páginas

128

Encuadernación

Tapa Dura

Dimensiones

24.4 x 17.0 x 1.0 cm

Peso

0.41 kg.

ISBN13

9781839685477

Categorías

Biología molecular

Lipid Peroxidation Research (en Inglés)

Mansour, Mahmoud Ahmed (Autor) · Intechopen · Tapa Dura

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Lipid Peroxidation Research (en Inglés)"

Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases.