Name: Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives (en Inglés)
Price: 77990.00 CLP
Availability: InStock
Author: Mogal, Azmin M. ; Noolvi, M. N.
ISBN: 9786200440037

portada Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives (en Inglés)

Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives (en Inglés)

Formato

Libro Físico

Autor

Azmin M. Mogal

M. N. Noolvi

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.5 cm

Peso

0.14 kg.

ISBN13

9786200440037

Categorías

Química

Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives (en Inglés)

Azmin M. Mogal (Autor) · M. N. Noolvi (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives (en Inglés)"

In this study we have synthesized and evaluated some newt tri-substitute imidazo [2, 1-b]- 1,3,4- thiadiazole derivatives comprising coumarin and imidazo [2, 1-b]- 1,3,4- thiadiazole moieties. We have reported a series of imidazo [2, 1-b]- 1,3,4- thiadiazole analogues to target MAPK. The compounds were synthesized by conventional methods and reaction process was monitored by TLC using suitable mobile phase and melting points of synthesized compounds were also determined. Furthermore, synthesized compounds were also characterized and confirmed by IR, 1H-NMR, 13C-NMR and Mass spectra. Two selected compounds were sent to NCI for anticancer screening and got results of both the compounds (6a & 6b). Compound 6a inhibited various cell lines with growth percentage of 140.30. Compound 6b inhibited different cell lines with growth percentage of 54.60. So, we conclude that, imidazo [2, 1-b]- 1,3,4- thiadiazole derivative containing Thiocynaide group (6a) is showing good anticancer activity than amino group-containing imidazo [2, 1-b]- 1,3,4- thiadiazole compound (6b). These results could offer an excellent framework in this field that may lead to discovery of potent anticancer agents.