Name: Untangling the Double Helix: Dna Entanglement and the Action of the dna Topoisomerases (en Inglés)
Price: 9030.00 CLP
Availability: InStock
Author: James C. Wang
ISBN: 9780879698799

portada Untangling the Double Helix: Dna Entanglement and the Action of the dna Topoisomerases (en Inglés)

Formato

Libro Físico

Editorial

Cold Spring Harbor Laboratory Press

Autor

James C. Wang

Año

2009

Idioma

Inglés

N° páginas

233

Encuadernación

Tapa Blanda

Peso

0.95

ISBN

0879698799

ISBN13

9780879698799

N° edición

Categorías

Bioquímica

Untangling the Double Helix: Dna Entanglement and the Action of the dna Topoisomerases (en Inglés)

James C. Wang (Autor) · Cold Spring Harbor Laboratory Press · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Untangling the Double Helix: Dna Entanglement and the Action of the dna Topoisomerases (en Inglés)"

The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled - Ânot just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.Related Titles from the Publisher Bioinformatics: Sequence and Genome Analysis, 2nd ed. Evolution Genes & Signals A Genetic Switch, 3rd ed., Phage Lambda Revisited Molecular Biology of the Gene, 6th ed.