Name: Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover (en Inglés)
Price: 227080.00 CLP
Availability: InStock
Author: Di, Li ; Kerns, Edward H.
ISBN: 9781118788356

portada Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover (en Inglés)

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover (en Inglés)

Formato

Libro Físico

Ilustrado por

Li Di

Edward H. Kerns

Editorial

Wiley

Autor

Di, Li ; Kerns, Edward H.

Idioma

Inglés

N° páginas

600

Encuadernación

Tapa Dura

Dimensiones

23.6 x 16.0 x 3.6 cm

Peso

0.92 kg.

ISBN13

9781118788356

N° edición

Categorías

Farmacología
Neurociencias
Bioquímica

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover (en Inglés)

Li Di (Ilustrado por) · Edward H. Kerns (Ilustrado por) · Wiley · Tapa Dura

Libro Nuevo Importado

Envío: 16 a 21 días háb.

$ 378.460$ 227.080

-40%

Costos de importación incluídos en el precio ✅

Libro Nuevo

Quedan más de 100 unidades

$ 227.080

Llega entre el 10 Ago y el 17 Ago a Santiago, Región Metropolitana. Seleccionar ubicación

Agregar a lista de deseos

Reseña del libro "Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover (en Inglés)"

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. - Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects - Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies - Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes - Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) - Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market