Name: G Protein Signaling: Methods and Protocols (en Inglés)
SKU: 25445120
Price: 106800.00 CLP
Availability: InStock
Author: Smrcka, Alan V.

portada G Protein Signaling: Methods and Protocols (en Inglés)

G Protein Signaling: Methods and Protocols (en Inglés)

Formato

Libro Físico

Editorial

Humana

Autor

Smrcka, Alan V.

Año

2010

Idioma

Inglés

N° páginas

250

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x1.5 cm

Peso

0.38 kg.

ISBN

1617373818

ISBN13

9781617373817

Categorías

Microbiología médica y virología
Bioquímica
Biología molecular

G Protein Signaling: Methods and Protocols (en Inglés)

Smrcka, Alan V. (Autor) · Humana · Tapa Blanda

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Reseña del libro "G Protein Signaling: Methods and Protocols (en Inglés)"

Since the initial discovery of the G protein-coupled receptor system that regulates cyclicAMP production, the G protein field has rapidly expanded. Cell surface receptors that couple to heterotrimeric G proteins, the G prote- coupled receptors (GPCRs), number in the hundreds and bind to a wide div- sity of ligands including, biogenic amines (e. g., adrenaline), lipid derivatives (e. g., lysophosphatidic acid), peptides (e. g., opioid peptides), proteins (e. g., thyroid-stimulating hormone), and odorants to name a few. The GPCR system is found throughout biology in such simple organisms as yeast and in such more complex organisms as Dictyostelium discoideum (slime mold), Caen- habditis elegans (nematode worm), and of course in humans. GPCRs and their associated G protein systems are the subject of intense academic research and because of their involvement in a human biology and disease, the pharmac- tical industry has large research initiatives dedicated to the study of GPCRs. By some estimates, more than 50% of the pharmaceuticals on the market are targeted at GPCRs.The G protein/G protein-coupled receptor system consists of a receptor (GPCR), a heterotrimeric G protein consisting of ?, ?, and ? subunits, and an effector. G protein effector molecules, such as enzymes or ion channels, respond to acti- tion by the G protein to generate second messengers or changes in membrane potential that lead to alterations in cell physiology.