Name: Mechanisms in Parkinson's Disease: Models and Treatments (en Inglés)
Price: 226590.00 CLP
Availability: InStock
Author: Dushanova, Juliana
ISBN: 9789533078762

portada Mechanisms in Parkinson's Disease: Models and Treatments (en Inglés)

Mechanisms in Parkinson's Disease: Models and Treatments (en Inglés)

Formato

Libro Físico

Editorial

Intechopen

Autor

Dushanova, Juliana

Idioma

Inglés

N° páginas

608

Encuadernación

Tapa Dura

Dimensiones

24.4 x 17.0 x 3.3 cm

Peso

1.16 kg.

ISBN13

9789533078762

Categorías

Neurología y neurofisiología clínicas

Mechanisms in Parkinson's Disease: Models and Treatments (en Inglés)

Dushanova, Juliana (Autor) · Intechopen · Tapa Dura

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Reseña del libro "Mechanisms in Parkinson's Disease: Models and Treatments (en Inglés)"

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.