Name: Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology) (en Inglés)
SKU: 57497100
Price: 151080.00 CLP
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Author: Caldwell Gary W.,Yan Zhengyin

portada Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology) (en Inglés)

Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology) (en Inglés)

Formato

Libro Físico

Editorial

Humana

Autor

Caldwell Gary W.,Yan Zhengyin

Idioma

Inglés

N° páginas

614

Encuadernación

Tapa Blanda

ISBN13

9781493960705

N° edición

Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology) (en Inglés)

Caldwell Gary W.,Yan Zhengyin (Autor) · Humana · Tapa Blanda

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Reseña del libro "Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology) (en Inglés)"

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates.Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.