Name: Rna as a Drug Target: The Next Frontier for Medicinal Chemistry (en Inglés)
SKU: 56147305
Price: 184380.00 CLP
Availability: InStock
Author: Schneekloth John,Pettersson Martin,Mannhold Raimund
ISBN: 9783527351008

portada Rna as a Drug Target: The Next Frontier for Medicinal Chemistry (en Inglés)

Rna as a Drug Target: The Next Frontier for Medicinal Chemistry (en Inglés)

Formato

Libro Físico

Editorial

Wiley-Vch

Autor

Schneekloth John,Pettersson Martin,Mannhold Raimund

Idioma

Inglés

Encuadernación

Tapa Dura

ISBN13

9783527351008

Rna as a Drug Target: The Next Frontier for Medicinal Chemistry (en Inglés)

Schneekloth John,Pettersson Martin,Mannhold Raimund (Autor) · Wiley-Vch · Tapa Dura

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Reseña del libro "Rna as a Drug Target: The Next Frontier for Medicinal Chemistry (en Inglés)"

Addressing a long-standing challenge for medicinal chemists, this practical reference provides the concepts and tools for developing drug-like small molecules that selectively modulate non-coding RNAs. The introductory parts describes the wide range of druggable RNAs, available techniques for their characterization, binding assay development as well privileged structures in small molecule RNA binders. The main part systematically covers different RNA targets and how to approach them from a drug discovery angle, from splice modulation to riboswitches to targeted degradation, translation blockers and RNA modification. Throughout, the first successful examples of RNA-targeting drug candidates from the development pipeline of small and large pharmaceutical companies are discussed. This seminal reference on a new paradigm in drug discovery is required reading for every medicinal chemists who needs to stay abreast of current developments.