Name: Role of ΔNp73 in oxaliplatin chemoresistance in colo-rectal cancer (en Inglés)
Price: 52570.00 CLP
Availability: InStock
Author: Sendino Garví, Elena
ISBN: 9786202120104

portada Role of ΔNp73 in oxaliplatin chemoresistance in colo-rectal cancer (en Inglés)

Formato

Libro Físico

Autor

Elena Sendino Garví

Editorial

Editorial Academica Espanola

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.3 cm

Peso

0.09 kg.

ISBN13

9786202120104

Categorías

Biología

Role of ΔNp73 in oxaliplatin chemoresistance in colo-rectal cancer (en Inglés)

Elena Sendino Garví (Autor) · Editorial Academica Espanola · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Role of ΔNp73 in oxaliplatin chemoresistance in colo-rectal cancer (en Inglés)"

Colorectal cancer is one of the most frequent types of cancer and has one of the highest mortality rates. As in all types of cancer, neoplasia is due to multiple factors, among which the environmental factor and the genetic factor stand out. The TP73 gene has been reported to be involved in colorectal cancer. Belonging to the TP53 gene family, it encodes multiple isoforms, such as TAp73 or ΔNp73, with opposite functions in the colorectal cancer carcinogenesis process. One of the isoforms, which is the subject of this study, ΔNp73, has been over-expressed in processes of tumorigenesis, as well as a potential cause of the resistance of cancer cells, contributing to a lower survival of patients with colorectal cancer. In this work, the over-expression of ΔNp73 has been identified as one of the possible causes of resistance by cancer cells to treatment with oxaliplatin (compound used in cancer chemotherapy), through the potential activation of the autophagy pathway, through the possible induction of the HMGB-1 gene, fact by means of which said resistance to oxaliplatin could be developing.