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Peptidomimetics In Organic And Medicinal Chemistry
Antonio Guarna, Andrea Trabocchi (Autor)
·
Wiley
· Cloth
Peptidomimetics In Organic And Medicinal Chemistry - Antonio Guarna, Andrea Trabocchi
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Origen: Reino Unido
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Reseña del libro "Peptidomimetics In Organic And Medicinal Chemistry"
A Peptidomimetic Is A Small Protein - Like Chain Designed To Mimic A Peptide With Adjusted Molecular Properties Such As Enhanced Stability Or Biological Activity. It Is A Very Powerful Approach For The Generation Of Small - Molecule - Based Drugs As Enzyme Inhibitors Or Receptor Ligands. Peptidomimetics In Organic And Medicinal Chemistry Outlines The Concepts And Synthetic Strategies Underlying The Building Of Bioactive Compounds Of A Peptidomimetic Nature. Topics Covered Include The Chemistry Of Unnatural Amino Acids, Peptide - And Scaffold - Based Peptidomimetics, Amino Acid - Side Chain Isosteres, Backbone Isosteres, Dipeptide Isosteres, Beta - Turn Peptidomimetics, Proline - Mimetics As Turn Inducers, Cyclic Scaffolds, Amino Acid Surrogates, And Scaffolds For Combinatorial Chemistry Of Peptidomimetics. Case Studies In The Hit - To - Lead Process, Such As The Development Of Integrin Ligands And Thrombin Inhibitors, Illustrate The Successful Application Of Peptidomimetics In Drug Discovery. Peptidomimetics In Organic And Medicinal Chemistry Will Find A Wide Readership Amongst Researchers And Students Who Are Involved In Medicinal Chemistry And Drug Discovery, Chemical Biology And Biochemistry
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